As an example of the combination of this approach with the monomolecular DNA particle technology
discussed above, we attempt targeting [27] of the high affinity (Ka ≈ 108 M-1 ) folic acid receptor which is overexpressed on many cancer cells. Folic acid binding triggers internalization of the complexes. PEG (M 53400) was conjugated to a dipalmitoylglycerolipid (DPPE), as an anchor to the lipid particle, and to folic acid on the distal end (Fig. 3)