Although adjusting the experimental design (increasing the dose or duration of NSAID treatment) allows researchers to il- lustrate fracture healing inhibition for al- most any NSAID studied in rodent models, it is important to acknowledge that even fractures in the NSAID-treated groups often go on to heal. Additionally, it some- times takes sensitive outcome measures (such as histomorphometry) to detect a significant difference between groups. It is impossible to make conclusions about clinical relevance in other species based on thesestudies.