C-reactive protein (CRP) is a plasma protein that increases in the systemic response to inflammatory events. Its rapid increase in synthesis within hours after tissue injury or infection suggests that it contributes to host defense and that it is part of the innate immune response. There is an association between elevation of this protein and future major cardiovascular events.17 Considering the role of ginger in reducing inflammation and given the fact that we could not find any study in the literature on the long-term effects of ginger on inflammation, this study was designed to determine the effect of daily supplementation of 1 g ginger powder for 3 months on inflammatory markers in older patients with knee OA.