Over the last century, these two ideas have utterly transformed our understanding of the universe. It's thanks to relativity and quantum mechanics that we've learned what the universe is made from, how it began and how it continues to evolve. A hundred years on, we now find ourselves at another turning point in physics, but what's at stake now is rather different. The next few years may tell us whether we'll be able to continue to increase our understanding of nature, or whether maybe for the first time in the history of science, we could be facing questions that we cannot answer, not because we don't have the brains or technology, but because the laws of physics themselves forbid it.