The role of the Clinical Nurse Leader (CNL)® restores this vital connection. The CNL is a clinician who brings the locus of control for safe and quality care from the administrative areas straight to the unit’s providers who deliver the services. “The CNL answers the call to rise above the staccato pace of fragmented and complex healthcare delivery and lead others to ensure that patient care is safe and effective” (Porter-O’Grady, Clark, & Wiggins, 2010, p. 40) In this article we describe the background and intent of the CNL role and explain how the CNL works both to facilitate a culture of safety and to enhance safety of the care for a group of patients. We show how the CNL enhances safety across diverse settings and conclude by noting the power that CNLs have for building continuing coalitions of safety. The value of the CNL as a front-line care leader for building and sustaining safer and higher quality care delivery environments for the future is highlighted.