Samples of low density polyethylene (LDPE) and blends of LDPE/thermoplastic starch (TPS) were processed using a single screw extruder for 5–10 times to simulate important features of recycling processes. LDPE and LDPE/TPS blends submitted to 0, 5 and 10 extrusion cycles were analyzed through thermal analysis using DSC, capillary rheometry, dynamic mechanical analysis, mechanical tests and contact angle measurements. The imposed extrusion cycles (covering the number of cycles tested, that is, up to 10) favored a reduction in the size of the TPS phases. Significant changes were not observed in the mechanical, rheological, and dynamic mechanical properties and the surface energy for LDPE and the LDPE/TPS blend after 5 cycles and 10 cycles of extrusion. Therefore, the results obtained in this study indicated that reprocessing (simulated here by up to 10 extrusion cycles), which is a fundamental part of recycling processes, does not significantly alter the properties of the LDPE/thermoplastic starch blends. Thus, the substitution of products based on LDPE with the LDPE/TPS blend may not result in appreciable changes in recyclability issues associated with reprocessing of the involved systems.