Sclerostin, a product of a SOST gene, is a protein expressed by osteocytes that inhibits
osteoblastic bone formation. Several hormones, including PTH and glucocorticosteroids,
have been suggested to be possible regulators of sclerostin production. The influence of
thyroid hormones on sclerostin synthesis has not been investigated, so far. The aim of the
study was to evaluate sclerostin concentrations in patients before and after treatment of
thyrotoxicosis.