In most parts of the world, soybean meal (SBM) is the main vegetable source of protein ingredients of com-mercial aquaculture feeds. Different soybean products, such as soy protein concentrate, extracted and defatted soybean meal, full-fat SBM, or low oligo-saccharide SBM (Refstie et al., 1998) produced contrasting growth because of the varied quantities of anti-nutrient compounds (trypsin, lectin, phytic acid and protease inhibitors) and/or lowly digestible carbohydrates present in these products. Different authors have also found problems of palatability or the existence of different components affecting SBM utilization in animals. Besides these variable results, SBM is not a readily available feedstuff worldwide. Therefore, there is a need to investigate the possibility of using other animal or vegetable protein sources with low market prices and nutritive value comparable to that of SBM. Less attention has been paid to the partial substitution of soybean in diets for tilapia. Adebayo et al. (2004) reported that Cassia fistula meal (CFM) could be a substitute for SBM up to (170 g /kg) in practical diets without compromising growth of O.niloticus fingerlings. Lim et al. (2001) concluded that palm kernel meal (PKM) could substitute up to 50% SBM in practical diet for O. mossambicus without much adverse effect to fish growth. Chien and Chin (2003) found that partial replacement of SBM protein with lupin seed protein in juvenile tilapia diets resulted in better growth and feed performance. Chareontesprasit and Jiwyam (2001) reported that, the replacement of soybean meal by wolffia meal could be possible only up to 15% in the ration and an increase beyond 15% would decrease total fish growth, survival rate, feed intake, and feed conversion ratio of Nile tilapia. However, there is no available information on the use of shrimp shell meal (SSM) or soybean and shrimp shell protein ratio as feed for tilapia.