Figure 2
ITT/LOCF change scores for cognition outcomes (ADAS-cog, SKT) by individual trial and pooled standardized mean difference compared with placebo.
Six studies with separate analyses for patients with Alzheimer's disease could be included for the subgroup evaluation. For the Alzheimer subgroup, the standardized change scores (ADAS-cog or SKT) were greater for ginkgo than for placebo, with SMD = -0.63 (95% CI -1.16; -0.10, z = 2.35, N = 6, p = 0.02). Heterogeneity remained high also in this subgroup (χ2 = 95.96, I2 = 95%).