The combination of these two assays would cover the three genotoxicity 418 endpoints described above, as the bacterial test detects gene mutations and the in vitro 419 micronucleus assay detects both structural and numerical chromosome aberrations. 420
Except for special cases for which the Ames test is not suitable, the SCCS 421 recommends the combination of the two assays for the base level testing of cosmetic 422 substances (SCCS/1532/14).