in which insulin sensitivity is estimated by using the fasting
and mean glucose and insulin concentrations in serum during the
OGTT. The first-phase insulin response was calculated with the
Stumvoll equation [1194 4.724*Ins0 117.0*Glu60
1.414*Ins60], which has been used previously in pregnant
women (17, 18). The second-phase insulin response was calculated
as 2950.349*Ins6025.72*Glu601.107*Ins0 (19).
An insulin secretion-sensitivity index was obtained by calculating
the product of the insulin sensitivity (Matsuda index) and the
first-phase insulin response (20). -Cell response was also estimated
using the oral disposition index, calculated as [(Ins
0–30/Glu 0–30) 1/fasting insulin