Andrographis paniculata is a medicinal plant with short life cycle. Can always find it easy and cheap. Research activity test and treat diarrhea sore throat in person. The test of acute toxicity in experimental animals. Has been proven to be safe no symptoms and also known to be used to relieve the microbial infections in animals. Which will help reduce the cost of production and reduce the problem of antibiotic residues in meat for consumption.In the form of pharmaceuticals that decent for the prevention and treatment of chicken to maximum efficiency. The Andrographis paniculata extract by methanol concentration 75% as extraction solvent.Effective in that part of pathogenic bacteria (Staphylococcus aureus ATCC 25923, Staphylococcus aureus BHU 011, Enterococcus faecalis ) in the digestive tract of the chicken. Better than the extract with water as the solvent in the extraction. But there is no effective in inhibiting (Pseudomonas aeruginosa ATCC 27853 Protius vulgaris,,Escherichia coli ATCC 35218) when tested with all bacteria indicated that the extract of Andrographis paniculata, which uses methyl ethanol concentration 70% solvent with low concentration of extract used in the inhibition of bacteria Which shows the clear width equals 18 mm utilization of Andrographis paniculata in inhibition of pathogenic bacteria in chicken found that the use of Andrographis paniculata 0.1% is good for polite chicken over another level. It is the use of Andrographis paniculata instead of antibiotics in the next.