The results of this randomized, double-blind trial demonstrated that the therapy of SP-NLC and SP-ALC were well tolerated and resulted in significantly greater improvement in mild to moderate acne vulgaris after 8 weeks treatment in comparison to the base- line. This therapy effectively treated non-inflammatory lesions, and showed high skin hydratation in the SP-NLC group (group A). However, the role of SP-NLC gel developed in the present investigation still requires clinical evaluation in a larger number of human subjects at different locations.