Non-parenteral routes of delivery possess low bioavailability and display various challenges in the successful delivery of proteins and peptides. Regardless of these challenges, the oral route of delivery still holds preference over other non-parenteral routes for systemic administration of active compounds as it is the most acceptable and convenient for the patient (Brown, 2005). The non-parenteral oral delivery of therapeutic proteins and peptides is by far the most popular route of delivery, making it an active area of research for many researchers and academic laboratories and is therefore the focus of this review (Zhou and Li Wan Po, 1991).