As shown in Fig 2, the model proposes that the main action of nutrition on the ovary is a direct inhibition of follicular oestradiol secretion by the insulin-glucose metabolic system (Somchit et al., 2007). We suggested that the insulin-glucose metabolic system has intrafollicular modulatoryactions as an “immediate” effect of nutrition. However, it is not possible to definitively exclude the insulin-glucose system from the mechanism of the “static” and “dynamic” effects. The precise intrafollicular and intracellular mechanisms of these effects are as yet unclear but what is clear is that this system is involved and that there are complex interactions among the insulin-glucose system in mediating follicular responses to nutrition.