Coffee consumption is used for social activity, leisure,improvement of work performance, and well-being. Coffeeis not only a medicinal alternative but also a beverage con-taining numerous potential health benefits. The results frommany types of research suggest the positive effects of cof-fee consumption on various aspects of health, as mentionedabove briefly. Despite the general good outcomes, it shouldbe emphasized that individual sensitivity to coffee and thebiological effects of coffee among humans may vary becauseof personal single nucleotide polymorphic variants, as shownin an investigation on genetic polymorphisms in apolipopro-tein E (APOE).15And some negative effects of coffee tend toemerge in excessive drinking, so it is the best to avoid heavycoffee intake. This minireview covers just a few of the healthbenefits and adverse effects associated with drinking coffee.Further studies on the functionally significant polymorphismsare needed for a better understanding of the effects of coffeeon personal health.