An ideal mass screening strategy for thalassemia or hemoglobinopathy carriers should be affordable and easily applicable in addition to the obvious requirements of accuracy and high sensitivity. The current standards-of- care for accurate detection of these disorders (HPLC, CZE or cIEF) are either not readily available in the majority of health centers, especially in rural parts of under-resourced countries, require expertise and experience to interpret [7] and are prone to interferences from nutritional deficiencies rife in these populations [8]. Experiences in Indian centers as well as recent publications from countries like Pakistan and South Korea indicate the continuing use of CAE+densitometry [3, 4]. The availability of automated versions of CAE prompted us to relook into its utility for the measurement of HbA2 and variants.