The small particle size of these nanopar- ticles ensures close contact with the stratum corneum and also increases the amount of encapsulated compounds penetrating into the skin due to the formation of an intact film on the skin surface upon drying. This lipid nanocarrier have been used to improve the skin/dermal uptake of several drugs such as cyproterone acetate [8], tretinoin [9], isotretinoin [10] and adapalene [11] which supports the notion that these nanocarriers can be employed for the topical delivery of SP.