Cellulose probably is the most abundant organic compound in the world which mostly produced by plants. It is the most structural component in herbal cells and tissues. Cellulose is a natural long chain polymer that plays an important role in human food cycle indirectly. This polymer has versatile uses in many industries such as veterinary foods, wood and paper, fibers and clothes, cosmetic and pharmaceutical industries as excipient. Cellulose has very semi-synthetic derivatives which is extensively used in pharmaceutical and cosmetic industries. Cellulose ethers and cellulose esters are two main groups of cellulose derivatives with different physicochemical and mechanical properties. These polymers are broadly used in the formulation of dosage forms and healthcare products. These compounds are playing important roles in different types of pharmaceuticals such as extended and delayed release coated dosage forms, extended and controlled release matrices, osmotic drug delivery systems, bioadhesives and mucoadhesives, compression tablets as compressibility enhancers, liquid dosage forms as thickening agents and stabilizers, granules and tablets as binders, semisolid preparations as gelling agents and many other applications. These polymeric materials have also been used as filler, taste masker, free-flowing agents and pressure sensitive adhesives in transdermal patches. Nowadays cellulose and cellulose based polymers have gained agreat popularity in pharmaceutical industries and become more and more important in this field owing to production of the new derivatives and finding new applications for existed compounds by pharmaceutical researchers.