DON, also known as vomitoxin due to its emetic effect sin pigs, is produced principally by Fusarium graminearum and Fusarium culmorum and is considered to be a majorcause of economic losses due to reduced growth perfor-mance. The mode of action of DON is explained by its abilityto bind to the 60S ribosomal subunit and to inhibit pro-tein synthesis. Moreover, DON activates mitogen-activatedprotein kinases (MAPKs) and cause apoptosis througha process known as “ribotoxic stress response” [34].DON exposure is generally associated with feed refusal,depressed feed intake, and possibly impaired immunefunction in many animal species [30]. The European Com-mission (EC) has published guidance levels for DON inproducts intended for animal feed. These guidance val-ues for DON are 8 mg kg−1in cereals and cereal products,12 mg kg−1in maize by-products and 5 mg kg−1in comple-mentary and complete feeding stuffs with the exception offeeding stuffs for pigs (0.9 mg kg−1), calves (