In our previous research we proposed an innovative type of stable
nanosized chiral metal oxide surface [16]. The structure and chirality
of this type of chiral surface is based on chiral self-assembled monolayers
(SAMs) coated with nanosized films of metal oxide materials
(e.g. TiO2). In Fig. 1 the overall design and synthetic paths for this chiral
SAM/metal oxide surface are shown. The fundamental principle of
design of these chiral surfaces is that themetal oxide nanolayers coating
the chiral SAMs protect the chiral SAMs that would otherwise be
destroyed under severe reaction conditions, while preserving their
enantioselectivity [14].