Interestingly, we found different associations between what appeared to be similar factors in men and women and subsequent risk of colorectal cancer. It is possible that women and men completed the FFQ differently resulting in different degrees of measurement error. If the reported diet in women had more random error, then associations would be attenuated compared to what we observed in the men. But the associations were not simply attenuated, as we actually observed stronger associations for the meat and potatoes factor in women. The use of MHT was more common among women with low scores on the meat and potatoes factor, and given previous studies showing a possible inverse association between MHT and colorectal cancer (41,42), this could, in part, explain the stronger association in women than in men for this variable. We did control for MHT use in multivariate models, but it is possible that we did so imperfectly and thus we cannot rule out residual confounding. There was no association between MHT and the fruit and vegetable factor scores, however, and yet we still saw differences in risk estimates for men and women on this variable. An alternate possibility is that genuine differences exist in the diet-related pathology of colorectal cancers between men
and women.
Interestingly, we found different associations between what appeared to be similar factors in men and women and subsequent risk of colorectal cancer. It is possible that women and men completed the FFQ differently resulting in different degrees of measurement error. If the reported diet in women had more random error, then associations would be attenuated compared to what we observed in the men. But the associations were not simply attenuated, as we actually observed stronger associations for the meat and potatoes factor in women. The use of MHT was more common among women with low scores on the meat and potatoes factor, and given previous studies showing a possible inverse association between MHT and colorectal cancer (41,42), this could, in part, explain the stronger association in women than in men for this variable. We did control for MHT use in multivariate models, but it is possible that we did so imperfectly and thus we cannot rule out residual confounding. There was no association between MHT and the fruit and vegetable factor scores, however, and yet we still saw differences in risk estimates for men and women on this variable. An alternate possibility is that genuine differences exist in the diet-related pathology of colorectal cancers between menand women.
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