Ethnopharmacological relevance:Maek

Ethnopharmacological relevance:Maekmoondong-tang (MMDT) isatraditionalherbalmedicationwidely
used toimprovecoughinKorea,Japan,andChina.Itiscomposedofsixherbs(OphiopogonisTuber,
Pinelliae Tuber,GlycyrrhizaeRadix,ZizyphiFructus,GinsengRadix,andOryzaeSemen).
Aim ofthestudy: This studyisaimedtosystematicallyreviewtherelevantrandomisedcontrolledtrials
(RCTs)todeterminetheeffectivenessandsafetyofMMDTforcough.
Materials andmethods: Electronic andhand-searchingof7databases(CochraneLibrary,MEDLINE,
EMBASE, OASIS,RISS,CNKIandCiNii)wassystematicallyconducteduptoFebruary2015forRCTstesting
MMDT inpatientswithcough.Theprimaryoutcomewascoughsymptomimprovementusingcough
diary,visualanalogscale,orresponserate.Riskofbiasoftheincludedtrialswasevaluatedwiththe
Cochrane riskofbiasassessmenttool.Thedichotomousdatawerepooledtoobtainariskratio(RR)of
cough persistingaftertreatment,with95%confidence intervals(CI).
Results: NineRCTsinvolving2453participantswereincluded.Themethodologicalqualitywaslargelypoorfora
majorityofthestudies.MMDTreducedtheseverityofcough by74%comparedwiththeconventionalantitussive
medicationsinvariousconditions(n¼1145;RRofcoughpersistingaftertreatment¼0.26;95%CI,0.19–0.34,
I2¼0%).TheadditionofMMDTtoconventionalmedication inpatientswithpostinfectiouscoughsignificantly
alleviatedsymptomsuptoday5buttheeffectwasnotmaintainedoneweekafterwards.Forotherdiseases/
conditions includingchronicobstructivepulmonarydisease,lungcancersurgery,andasthma,theevidenceis
inconsistentforMMDT/mMMDTforcough.Adverseeventsappeartoberarebutthereportingwaspoor.
Conclusions: The currentevidencefromoursystematicreviewandmeta-analysisonMMDTforcoughisin-
conclusiveandweproposethatrigorouslydesigned,placebo-controlledtrialsofMMDTshouldbeconductedto
establishitsplaceinmanagementofcough.
& 2015ElsevierIrelandLtd.Allrightsreserved

ผลลัพธ์ (ไทย) 1:

Ethnopharmacological relevance:Maekmoondong-tang (MMDT) isatraditionalherbalmedicationwidelyused toimprovecoughinKorea,Japan,andChina.Itiscomposedofsixherbs(OphiopogonisTuber,Pinelliae Tuber,GlycyrrhizaeRadix,ZizyphiFructus,GinsengRadix,andOryzaeSemen).Aim ofthestudy: This studyisaimedtosystematicallyreviewtherelevantrandomisedcontrolledtrials(RCTs)todeterminetheeffectivenessandsafetyofMMDTforcough.Materials andmethods: Electronic andhand-searchingof7databases(CochraneLibrary,MEDLINE,EMBASE, OASIS,RISS,CNKIandCiNii)wassystematicallyconducteduptoFebruary2015forRCTstestingMMDT inpatientswithcough.Theprimaryoutcomewascoughsymptomimprovementusingcoughdiary,visualanalogscale,orresponserate.RiskofbiasoftheincludedtrialswasevaluatedwiththeCochrane riskofbiasassessmenttool.Thedichotomousdatawerepooledtoobtainariskratio(RR)ofcough persistingaftertreatment,with95%confidence intervals(CI).Results: NineRCTsinvolving2453participantswereincluded.Themethodologicalqualitywaslargelypoorforamajorityofthestudies.MMDTreducedtheseverityofcough by74%comparedwiththeconventionalantitussivemedicationsinvariousconditions(n¼1145;RRofcoughpersistingaftertreatment¼0.26;95%CI,0.19–0.34,I2¼0%).TheadditionofMMDTtoconventionalmedication inpatientswithpostinfectiouscoughsignificantlyalleviatedsymptomsuptoday5buttheeffectwasnotmaintainedoneweekafterwards.Forotherdiseases/conditions includingchronicobstructivepulmonarydisease,lungcancersurgery,andasthma,theevidenceisinconsistentforMMDT/mMMDTforcough.Adverseeventsappeartoberarebutthereportingwaspoorบทสรุป: currentevidencefromoursystematicreviewandmeta-analysisonMMDTforcoughisin -conclusiveandweproposethatrigorouslydesigned, controlledtrialsofMMDTshouldbeconductedto ยาหลอกestablishitsplaceinmanagementofcoughและ 2015ElsevierIrelandLtd.Allrightsreserved

ผลลัพธ์ (ไทย) 3:

ethnopharmacological The maekmoondong Tang ( mmdt ) isatraditionalherbalmedicationwidely
ใช้ toimprovecoughinkorea , ญี่ปุ่น , และประเทศจีน . itiscomposedofsixherbs ( ophiopogonistuber
pinelliae , หัว , glycyrrhizaeradix zizyphifructus ginsengradix , , , andoryzaesemen )
:
studyisaimedtosystematicallyreviewtherelevantrandomisedcontrolledtrials ofthestudy นี้จุดมุ่งหมาย( RCTs ) todeterminetheeffectivenessandsafetyofmmdtforcough .
วัสดุและวิธีการ : andhand-searchingof7databases อิเล็กทรอนิกส์ ( cochranelibrary Medline , โอเอซิส , ริส , embase
, ,
cnkiandcinii ) wassystematicallyconducteduptofebruary2015forrctstesting mmdt inpatientswithcough . theprimaryoutcomewascoughsymptomimprovementusingcough
ไดอารี่ visualanalogscale orresponserate , .riskofbiasoftheincludedtrialswasevaluatedwiththe
Cochrane riskofbiasassessmenttool . thedichotomousdatawerepooledtoobtainariskratio ( RR )
ไอ persistingaftertreatment ช่วงความเชื่อมั่น with95 % ( CI ) .
ผล : ninerctsinvolving2453participantswereincluded . themethodologicalqualitywaslargelypoorfora by74 % comparedwiththeconventionalantitussive

majorityofthestudies.mmdtreducedtheseverityofcoughmedicationsinvariousconditions ( N ¼ว ; rrofcoughpersistingaftertreatment ¼ 0.26 ; 95% CI , 0.19 และ 0.34 ,
I2 ¼ 0 % ) theadditionofmmdttoconventionalmedication inpatientswithpostinfectiouscoughsignificantly
alleviatedsymptomsuptoday5buttheeffectwasnotmaintainedoneweekafterwards . forotherdiseases /
เงื่อนไข includingchronicobstructivepulmonarydisease lungcancersurgery andasthma theevidenceis
, , ,inconsistentformmdt / mmmdtforcough . adverseeventsappeartoberarebutthereportingwaspoor .
สรุป : currentevidencefromoursystematicreviewandmeta analysisonmmdtforcoughisin -
conclusiveandweproposethatrigorouslydesigned , placebo establishitsplaceinmanagementofcough controlledtrialsofmmdtshouldbeconductedto
.
& allrightsreserved 2015elsevierirelandltd .