You can take the IBU but it is not necessary. In fact since IBU temporarily halts the production of the mucous cell layer which is the protective layer of the stomach, intestines, and all organs it is better to take it later after drinking. If done often you make the possibility of the development of an ulcer mush more likely as the alcohol irritates the stomach cells/lining. It is better to take the IBU after you have drank and with a meal or sandwich at least.