In addition, the low percentage of dissolved drug obtained in our results could be explained by the higher particle size presented by ASA crystals (695 ± 27 µm). To prove our hypothesis we carried out dissolution tests of ASA crystals presenting mean diameter less than 500 µm, obtained by sieving, under the same test conditions previously presented. After 30 minutes, the amount of ASA dissolved was 88.26 ± 5.31%, showing the influence of the crystal mean size on its dissolution.