Using the Dermatude Meta-Ject FX 50 and the hand piece with ultra-thin needles are micro-perforations made in the skin. This treatment is moreover not painful. The skin will repair these invisible micro perforations immediately and will produce collagen and elastin, so the natural repair mechanisms of the skin comes into force. The skin is from the inside restored by cell regeneration, a completely natural process that does all the skin itself. Moreover, in the treatment of the active substances in the form of Subjectables placed on the skin, which can be highly specific and targeted treatments are carried out depending on skin type and purpose of the treatment. The subjectables support the natural cell regeneration of the skin.