Pharmacological studies revealed that
such compounds exhibited an array of diverse
bioactivities. Considering the data,
some conclusions could be drawn that the
S. acmella extracts and its constituting
compounds such as spilanthol and flavonoids
have been shown to possess inhibitory
activity toward PG synthesis. It could be
presumably proposed that these compounds
share a common functional group
with electrophilic center, interacting with
COX enzymes through nucleophilic addition
of serine residues.