Acute toxicity studies revealed the non-toxic of CCM extract and the its fractions. There were no lethality or toxic reactions found at any doses selected. The CCM extract,CCES,CCAS and CCAIS fractions showed a significant reduction in blood glucose levels from 30 min onwards in oral glucose tolerance test.
The most significant antidiabetic activity was observed with metformin at dose level of 50 mg/kg.
While comparing with the diabetic control ,amongst the extract and its fractions, CCM extract and CCES fraction have significantly lowered the rlevated blood glucose level.
The most prominent antidiabetic activity was observed by CCES fraction (64.5%) at dose level of 400 mg/kg, per oral after 24 hr.
While the CCAS fraction marginally lowered the blood glucose level in both the selected doses and CCAIS fraction was found to be inactive at the dose level of 400 mg/kg of body weight . Results obtained from experiment revealed that extract and its fractions have shown antidiabetic activity in decreasing order of .....