Combination Therapy
Combination therapy may be used in patients who remain symptomatic on initial medication therapy. There are several potential advantages of combination therapy as current Pulmonary hypertension therapies act on 3 different yet potentially complementary mechanisms. The clinician may add a second or even a third medication to the regimen to improve exercise tolerance and symptoms. This type of therapy may be warranted if the patient has had a response to the initial therapy but it’s not satisfactory. Combination therapy has become the standard of care in most Pulmonary hypertension centers; numerous case series have suggested that various medication combinations have proven to be safe and effective.13-15 To date, clinical trials continue to be completed to gather evidence in support of combination therapy.