Twenty lactic acid bacteria were screened for the abilities of rat intestinal α-glucosidase inhibition,
short-chain fatty acids production, utilization of prebiotics as well as gastrointestinal
tract tolerance. Nine strains inhibited α-glucosidase, four of which, Lactobacillus acidophilus
CCFM6, Lactobacillus plantarum CCFM47, CCFM232 and Lactobacillus rhamnosus GG (LGG) were
tolerant to simulated gastrointestinal juices with survival rates up to 60% following simulated
digestion. When grown on soybean oligosaccharides (SBOs), CCFM47 produced propionic
(39.9 mM) and butyric (3.5 mM) acids while strain CCFM6 produced 17.2 mM propionic acid.
Strains CCFM6 and CCFM47 were further tested for their viability and survival in set yoghurt
supplemented with SBOs. SBOs enriched yoghurt improved probiotic survival in the simulated
gastric juice and significantly improved α-glucosidase inhibition (P < 0.05). Thus strains
CCFM47 and CCFM6 can be used as probiotics with antihyperglycaemic potential in the formulation
of functional foods such as yoghurt
Twenty lactic acid bacteria were screened for the abilities of rat intestinal α-glucosidase inhibition,short-chain fatty acids production, utilization of prebiotics as well as gastrointestinaltract tolerance. Nine strains inhibited α-glucosidase, four of which, Lactobacillus acidophilusCCFM6, Lactobacillus plantarum CCFM47, CCFM232 and Lactobacillus rhamnosus GG (LGG) weretolerant to simulated gastrointestinal juices with survival rates up to 60% following simulateddigestion. When grown on soybean oligosaccharides (SBOs), CCFM47 produced propionic(39.9 mM) and butyric (3.5 mM) acids while strain CCFM6 produced 17.2 mM propionic acid.Strains CCFM6 and CCFM47 were further tested for their viability and survival in set yoghurtsupplemented with SBOs. SBOs enriched yoghurt improved probiotic survival in the simulatedgastric juice and significantly improved α-glucosidase inhibition (P < 0.05). Thus strainsCCFM47 and CCFM6 can be used as probiotics with antihyperglycaemic potential in the formulationof functional foods such as yoghurt
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