Chemosensors for selective detection of various biologically and environmentally relevant metal ions have recently attracted great attention. The widespread use of aluminum in food additives, aluminum-based pharmaceuticals, and storage/cooking utensils often exposes people to aluminum ions. In addition, frequent use of aluminum foil, vessels, and trays for convenience results in moderate increases in the Al3+ concentration in food. After absorption, aluminum ions
would be distributed to all tissues in humans and animals and eventually accumulate in the bone. The iron binding protein is known to be the main carrier of Al3+ in plasma, and Al3+ can enter the brain and reach the placenta and fetus. Aluminum ions may stay for a very long time in various organs and tissues before being excreted through the urine.