Author/Study Year Findings
Walker, et al. 2009 When evaluating post-menopausal women with PHPT, found weaker baseline performance in cognitive testing, independent of
neuropsychological symptoms. Patients that underwent PTX, improved in nonverbal abstraction.
Roman, et al. 2011 Correlated a postoperative decrease in PTH with a decrease in anxiety and cognitive errors.
Benge, et al. 2009 Found a trend of improved results on timed tests and depression assessment in postoperative patients, but decline in memory.
Walker, et al. 2004 Using the Epworth Sleepiness Scale, found an association between PHPT and sleep disturbances/circadian rhythm.
Perrier, et al. 2009 Demonstrated that improved sleep and decreased daytime sleepiness correlated with decreased PTH levels.
PTX = parathyroidectomy PTH = parathyroid hormone
PHPT = primary hyperparathyroidism
Table 2: Studies evaluating the effects of parathyroidectomy on neurocognitive function.