The observed yield loss after ten days of
pre-treatment and 4 108 spores 25 g1 substrate, however, might
be related to overcrowding of spores causing an inhibition of germination
and development, ‘‘catabolite repression’’ of the cellulase
system or due to the depletion of macro- and micronutrients altering
the fungal physiology (Nochure et al., 1993; Ghanem et al.,
2000).