These materials have received further interest as a proper support to form cross-linked aggregates (CLEAs) of enzymes in their cages [32–34], which show several advantages [35]: (1) no pre-precipitation of enzyme is necessary because the enzymes naturally aggregate in the cages of the solid through adsorption; (2)the growth of the aggregates is limited by the size of the cage;and (3) leaching can be suppressed due to size of the CLEAs, which exceeds the size of the entrances and (4) the diffusion of substratesis feasible through the interconnected cages.