Results: Exploratory factor analysis grouped the biomarkers under 5 factors. The composition of these groups
was partially unexpected but biological plausible. In multivariable analysis, only 1 factor proved to be an independent
predictor of outcome. Major contributions (factor loadings>0.50) in this cluster came from: midregional
pro-adrenomedullin, tumor necrosis factor receptor, pro-endothelin-1, growth differentiation factor
15, C-terminal pro arginine vasopressin, uric acid, chromogranin A and procollagen type III N-terminal.