Studies evaluating the ultimate function in skeletal muscle subjected to I-R injury may be more important and clinically relevant. Surgical restoration of blood flow following a traumatic crush injury or amputation may result in a viable extremity, but if a significant of the muscle dies from I-R injury then fibrosis will occur and function will be compromised. A study in progress by Zamboni et al. (40) employs a rabbit hindlimb model of physiologic amputation that simulates the clinical