With the aim of finding novel biomaterials with antimicrobial activity, the present work studies the thermo-rheological response, biocide release behaviour and the inhibitory effects against four selected pathogens of protein-based bioplastics in which two types of active agents (formic acid and oregano essential oil) were incorporated. Selected proteins (wheat gluten or egg-white albumen) would also allow for taking advantage of the low solubility and high swelling in water of the resulting bioplastics in order to develop controlled-release matrix for bioactive agents. In this regard, previous works on bioplastic from these proteins have shown enhanced water resistance (protein solubility below 5%) and high water absorption capability (up to 300%) depending on material formulation and processing (Jerez et al., 2007b;Zแrate-Ramํrez et al., 2011).