This updated guidance is intended to assist air medical transport (AMT) service providers in using specialized and/or specially equipped aircraft to transport Middle East Respiratory Syndrome (MERS) patients while ensuring the safety of patients and transport personnel. This guidance does not apply to commercial passenger aircraft. The recommendations are based on standard infection prevention and control practices, AMT standards, and epidemiologic information from investigations of MERS, including experience from air transport of patients during the 2003 SARS outbreak.