This was duly achieved in Beale 's laboratory by Sonia Morgan, working towards her Ph.D., who successfully selected a line of P.yoelii 17x(clone A) for resistance to pyrimethamine.
The stage was now set for the first laboratory rodent malaria parasite cross. Passing gametocytes of two strains through mosquitoes and showing that the resulting progeny population contained parasites carrying markers from both parents would be proof that recombination had occurred