Benign lymphangioendothelioma is a proliferation of lymphatic endothelial cells that stain positively for CD31, CD34, podoplanin (D2-40, a lymphatic marker), LYVE-1, and PORX-1.[4] Benign lymphangioendothelioma is not associated with preexisting vascular malformations or lymphedema. Although the lesion rarely is identified during infancy, some suggest it is a hamartoma that first becomes apparent during adolescence or young adult life; the development of benign lymphangioendothelioma is possibly triggered by hormonal changes.