Food is a major source of AGEs and these exogenous AGEs are
an important contributor to the body AGE pool as they have the
same pro-oxidative and proinflammatory actions as their
endogenous counterparts [17]. Food-derived AGEs are associated
with the development of IR, diabetes, renal disease, and
atherosclerosis in mice. Emerging data from several clinical trials
support an important role for a high intake of exogenous AGEs in
generating increased oxidative stress and inflammation. More
importantly, these trials have shown that reducing the dietary
AGE content decreases the high oxidative stress characteristic of
most chronic diseases [37,38]. A group of women with MetS
treated with a calorie-restricted diet with moderate carbohy-
drate restriction showed decreased diastolic blood pressure and
lower prevalence of MetS