Oncogenic Ras promotes glucose fermentation and glutamine
use to supply central carbon metabolism, but how
and why have only emerged recently. Ras-mediated metabolic
reprogramming generates building blocks for growth
and promotes antioxidant defense. To fuel metabolic
pathways, Ras scavenges extracellular proteins and lipids.
To bolster metabolism and mitigate stress, Ras activates
cellular self-cannibalization and recycling of proteins and
organelles by autophagy. Targeting these distinct features
of Ras-driven cancers provides novel approaches to cancer
therapy