In conclusion, we hereby report strong anti-atherogenic properties of diets containing both wild rice and phytosterols in LDL-r-KO mice. Potential mechanisms for such effects may include beneficial alterations in lipoprotein metabolism. As compared to control group, a significant reduction in plasma total, LDL and VLDL cholesterol concentrations was observed. This effect was accompanied by a significant increase in fecal cholesterol excretion. Altogether, this study provide evidence that long term consumption of wild rice in combination with phytosterols is safe and reduces cardiovascular risk factors in LDL-r-KO mice. Further investigation of exact mechanisms of action plus potential clinical outcome of such dietary approach in patients with cardiovascular risk factors is warranted.