Materials and methods
Subjects
We screened 80 healthy Filipino female candidates and
selected 30 subjects who met the criterion of only a small
difference in the melanin index between the left and right
sides of the face. These 30 subjects satisfied the additional
inclusion criteria of age 30 to 50 years and face melanin index
value of 200 to 350. The study was conducted at Clinical
Trial Management and Testing Associates, Inc. (Muntinlupa
City, Philippines). The study objectives and protocol were
carefully explained to the subjects and their written informed
consent was obtained.