How did dietary intake of WBM lead to an accelerated sIgA secretion in saliva? The IgA response is promoted by the regulatory activities of T-cell helper type 2 cytokines, integrins, and chemokines secreted within the tissues of the mucosal immune system linking the gut and other mucosal sites such as the salivary and mammary glands through the traffic of effector cells [3,6,7].