Because obesity are mandatory treated with weight reduction, we
have performed a discriminative study comparing the effects of
energy restriction with different dietary macronutrient composition
on weight loss, cardiovascular risk factors and protein secretion from
adipose tissue in obese humans. A high-protein/low carbohydrate
hypocaloric diet shows a higher weight loss, insulin and HOMA-R
decreased after 9 months than a standard hypocaloric diet. The improvement
in adipokine levels was similar with both diets.