Background:Urinarytractinfections(UTIs)areaverymostcommontypeofinfectionworldwide,andresultinbillionsofdollarsinmedicalcarecosts.Escherichiacoliistheinfectiveagentfor80–90%ofallUTIs.Greentea,derivedfromleavesoftheCamelliasinensisplanthasbeenshowntohavevariouspotentialhealthbenefits(e.g.,cardiovasculardiseaseandcancer).Themajorbeneficialcomponentsofgreenteahave,beencharacterized,andarenowknowntobepolyphenoliccatechins.Themaincatechinsingreenteaare(−)-epicatechin-3-gallate,(−)-epigallocatechin(EGC),(−)-epicatechin,and(−)-epigallocatechin-3-gallate(EGCG).EGCGandEGChavebeenshowntohavethegreat-estantimicrobialeffects,butonlyEGChasbeenshowntobeexcretedinurine.IsolatesofE.colifromUTIscollectedbetween2007and2008werecharacterizedforantimicrobialresistancetostandarddrugs.Then80oftheseisolates,representingawidespectrumofantimicrobialsusceptibilitypatterns,wereselectedfortestingusinganextractofgreentea.
พื้นหลัง: Urinarytractinfections (รถตรงมายัง) areaverymostcommontypeofinfectionworldwide, andresultinbillionsofdollarsinmedicalcarecosts Escherichiacoliistheinfectiveagentfor80–90%ofallUTIs.Greentea,derivedfromleavesoftheCamelliasinensisplanthasbeenshowntohavevariouspotentialhealthbenefits(e.g.,cardiovasculardiseaseandcancer) Themajorbeneficialcomponentsofgreenteahave, beencharacterized, andarenowknowntobepolyphenoliccatechins Themaincatechinsingreenteaare(−)-epicatechin-3-gallate,(−)-epigallocatechin(EGC),(−)-epicatechin,and(−)-epigallocatechin-3-gallate(EGCG) EGCGandEGChavebeenshowntohavethegreat-estantimicrobialeffects,butonlyEGChasbeenshowntobeexcretedinurine.IsolatesofE.colifromUTIscollectedbetween2007and2008werecharacterizedforantimicrobialresistancetostandarddrugs.Then80oftheseisolates,representingawidespectrumofantimicrobialsusceptibilitypatterns,wereselectedfortestingusinganextractofgreentea.
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Background:Urinarytractinfections(UTIs)areaverymostcommontypeofinfectionworldwide,andresultinbillionsofdollarsinmedicalcarecosts.Escherichiacoliistheinfectiveagentfor80–90%ofallUTIs.Greentea,derivedfromleavesoftheCamelliasinensisplanthasbeenshowntohavevariouspotentialhealthbenefits(eg,cardiovasculardiseaseandcancer).Themajorbeneficialcomponentsofgreenteahave,beencharacterized,andarenowknowntobepolyphenoliccatechins.Themaincatechinsingreenteaare(−)-epicatechin-3-gallate,(−)-epigallocatechin(EGC),(−)-epicatechin,and(−)-epigallocatechin-3-gallate(EGCG).EGCGandEGChavebeenshowntohavethegreat-estantimicrobialeffects,butonlyEGChasbeenshowntobeexcretedinurine.IsolatesofE.colifromUTIscollectedbetween2007and2008werecharacterizedforantimicrobialresistancetostandarddrugs.Then80oftheseisolates,representingawidespectrumofantimicrobialsusceptibilitypatterns,wereselectedfortestingusinganextractofgreentea.
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ประวัติ : urinarytractinfections ( UTIs ) areaverymostcommontypeofinfectionworldwide andresultinbillionsofdollarsinmedicalcarecosts , . escherichiacoliistheinfectiveagentfor80 – 90% ofallutis . กรีนที derivedfromleavesofthecamelliasinensisplanthasbeenshowntohavevariouspotentialhealthbenefits , ( เช่น cardiovasculardiseaseandcancer ) themajorbeneficialcomponentsofgreenteahave beencharacterized , ,andarenowknowntobepolyphenoliccatechins . themaincatechinsingreenteaare ( − ) - epicatechin-3-gallate , ( − ) - epigallocatechin ( egc ) , ( − ) - แคเทชินและ ( − ) - epigallocatechin-3-gallate ( EGCG ) egcgandegchavebeenshowntohavethegreat estantimicrobialeffects butonlyegchasbeenshowntobeexcretedinurine.isolatesofe.colifromutiscollectedbetween2007and2008werecharacterizedforantimicrobialresistancetostandarddrugs , .then80oftheseisolates representingawidespectrumofantimicrobialsusceptibilitypatterns wereselectedfortestingusinganextractofgreentea , , .
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