l, acitretin is esterified in vivo to produce etretinate, which has a t1/2 of >3 months (Vahlquist et al., 2008). It is not known how much alcohol (i.e., cough syrup or other alcohol-based medications) is required to induce this conversion. Therefore, female patients of childbearing age should avoid pregnancy for 3 years after receiving acitretin to avoid retinoid-induced embryopathy