In this large prospective study, coffee drinking was inversely associated with malignant melanoma. We found that as compared with non–coffee drinkers, those who drank the most coffee (≥4 cups/day) had a 20% lower risk of malignant melanoma but not of melanoma in situ, which may indicate different disease etiologies or an inhibitory role of coffee consumption in disease progression. Statistically significant inverse associations were also found for caffeinated coffee intake and malignant melanoma but not for decaffeinated coffee intake.