This application revealed practical implications when using SNP data for MRA. These can be summarized by
considering the following main issues: optimum sample size for valid inference on population level, correction
for population structure, quantification and calibration of results, reproducibility of the analysis, links with
epidemiological data, anchoring and integration of results into a systems biology approach for the translation of
molecular studies to human health risk.
Future developments in genetic data analysis forMRA should aimat resolving themapping problemof processing
genetic sequences to come to a quantitative description of risk. The development of a clustering scheme focusing
on biologically relevant information of themicrobe involvedwould be a useful approach inmolecular data reduction
for risk assessment.